Why CBD Improves Cases of Lennox-Gastaut Syndrome At first, CBD inhibits the inhibitory receptor: this is the biological equivalent of a double negative, 1dis – 2inhibiting the activity of the cell in which the CB1 receptor is located. However, the body’s natural response to negative activity is to compensate with positive feedback: in the presence of CBD, the brain actually creates MORE of the inhibitory CB1 receptors. This produces the end net result of raising the excitatory threshold of neurons, by increasing their resting level of inhibition (resting inhibition is correlated to the quantity of cannabinoid receptors).
In essence, CBD indirectly increases the natural process by which your brain inhibits unwanted activity like seizures: the endocannabinoid system (ECS). By increasing the inhibitory presence of the ECS, CBD increases the threshold amount of excitation required to elicit a neuronal response.
Similarly, THC in tandem with CBD is an even more potent anti-epileptic remedy. This makes sense, because CBD increases the amount of CB1 receptors available for THC to activate, thereby inhibiting neuronal activity more than it would have without the presence of CBD. THC takes advantage of the effect of CBD to increase the expression of CB1 receptors